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KMID : 0981820060260060431
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Korean Journal of Laboratory Medicine
2006 Volume.26 No. 6 p.431 ~ p.435
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Comparison of Three Assay Systems for Qualitative and Quantitative Results of Hepatitis B Surface Antibody
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Yoo Soo-Jin
Oh Hye-Jun
Shin Bo-Moon
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Abstract
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Background: With a technical improvement of the assay system, automated immunoassay analyzers for hepatitis B surface antibody (anti-HBs) are widely used. However, some discrepancies between assays are still being reported. We compared the qualitative and quantitative results of three kinds of anti-HBs assays.
Methods: Serum samples were collected from 517 patients and anti-HBs were determined using AxSYM AUSAB, Bayer ADVIA Centaur, and Roche Elecsys assay systems.
Results: The concordance rates between the three assays were 95.1% (543/571). The concordance rates were 97.7% between Centaur and Elecsys, 96.3% between AxSYM and Centaur, and 95.6% between AxSYM and Elecsys. Their correlation coefficients for quantitative results were 0.97, 0.94, and 0.93 in the same order. Twenty-eight specimens showed discrepant results, and all of them had antibody values below 31.5 mIU/mL.
Conclusion: Three immunoassays for anti-HBs presented a high concordance and correlation; however, the results should be interpreted with caution, because there were still significant differences between assay methods, especially for a low-level of anti-HBs. (Korean J Lab Med 2006;26:431-5)
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KEYWORD
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Hepatitis B virus, Anti-HBs, Automated immunoassay
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